One of Deodato's first works was a 1993 photo-realistic comic book adaptation of the television series Beauty and the Beast published by Innovation Publishing. Deodato became famous in the North American comic book industry for his work with writer William Messner-Loebs on Wonder Woman. After his Wonder Woman project he had a short stint as the penciller of The Mighty Thor, where he worked with writer Warren Ellis, and later drew Glory for Rob Liefeld's Extreme Studios at Image Comics and Maximum Press.