Nathaniel Meserve (1704–1758) was an American shipbuilder. Meserve was born in Portsmouth, New Hampshire, to Clement Maserve and his wife Elizabeth Jones. On December 16, 1725, aged 21, he married Jane Libby and together they had ten children. Nathaniel Meserve would become a shipwright in his native Portsmouth, a hub of early American shipbuilding. In 1758 Col. Nathaniel Meserve was with General Amherst in another attack on Fortress Louisbourg because of his service in the 1745 capture of the fort. Here he contracted smallpox and died along with his eldest son.