In 1827, Vladimir Istomin graduated from the Naval College. That same year, he then took part in the Battle of Navarino and later in the blockade of the Dardanelles (1828-1829). In 1836, Istomin was transferred from the Baltic Fleet to the Black Sea Fleet. In 1850, he was appointed commander of the battleship Paris (Париж), which would participate in the Battle of Sinop in 1853. During the siege of Sevastopol, Vladimir Istomin was in charge of the defense of the Malakhov Mound (Малахов курган) and nearby redoubts, setting an example of bravery and tenacity. He was killed by a cannonball on the Kamchatka redoubt on March 7, 1855.