The organization of the Midwest Collegiate Athletic Conference (MCAC) was conceived at a meeting at Coe College on May 12, 1921. Charter members were Beloit College, Carleton College, Coe College, Cornell College, Knox College (Illinois) and Lawrence University. Hamline University and Millikin University joined the league in December 1921, but both of them later withdrew: Hamline after the 1929-30 academic year, and Millikin after the 1924-25 academic year, respectively.