He made his name recording and touring with Frank Zappa, and went on to form Missing Persons with his then-wife and lead vocalist Dale Bozzio, ex-Zappa guitarist Warren Cuccurullo, ex-Zappa bassist Patrick O'Hearn and keyboard player Chuck Wild. More recently, he has worked with Jeff Beck, Steve Vai, Fantômas and Korn. Bozzio was inducted into Guitar Center's RockWalk in Hollywood in 2006.