A chemistry student invents a spray that makes its wearer invisible. Dexter Riley, a science major at Medfield College, along with fellow science majors Schuyler and Debbie concocts an invisibility spray. But when a gang of thieves find out about it and plan to steal it it's up to Dexter and friends to stop him. The gang, headed by A.J. Arno want the formula to use in a bank robbery. The kids find themselves being chased by the crooks. Meanwhile, Dexter employs the spray at a golf tournament, much to the surprise of apoplectic college Dean, Higgins.