Slithe was one of the primary antagonists of the 1985 Thundercats cartoon series. A large anthropomorphic lizard, Slithe was the leader of the faction of the evil Mutants present on Third Earth. Slithe was one of the three original Mutants to follow the Thundercats to Third Earth. Shortly afterwards he, Monkian, and Jackalman met the undead sorcerer Mumm-Ra. Mumm-Ra buried their ship beneath the sands outside their pyramid and forced the Mutants to become his servants.