A mixed, intermediate-acting insulin made by Novo Nordisk containing 20% R/neutral insulin and 80% NPH/isophane insulin crystals. Comparable product is also made by Novo: Actraphane 20/80. Eli Lilly once produced a similar insulin in the EU & UK called Humulin M2; it was discontinued in July 2004. Mixtard 20 was discontinued December 31, 2007.