Jim Cain (born 1939) is a former Grey Cup champion Canadian Football League offensive lineman. Cain was a graduate of the University of Detroit, returning to Canada to play for the Ottawa Rough Riders. A dependable player, who never missed a game in his 9 years, he finished his career with back-to-back Grey Cup championships. His cousin was Brian Smith of Ottawa, a former National Hockey League goalie and popular sportscaster who was tragically murdered in 1995.