SS Mission San Luis Obispo was a Type T2-SE-A2 tanker built for the United States Maritime Commission during World War II. After the war she was acquired by the United States Navy as USS Mission San Luis Obispo (AO-127). Later the tanker transferred to the Military Sea Transportation Service as USNS Mission San Luis Obispo (T-AO-127). A Mission Buenaventura-class oiler, she was named for Mission San Luís Obispo de Tolosa in San Luis Obispo, California.