The television show is a horror thriller/mystery, described as Scream meets And Then There Were None. The show takes place on Harper's Island, where John Wakefield went on a killing spree and murdered a number of people before supposedly being killed by the island sheriff, Charlie Mills. One of the victims was the sheriff's wife. After her death, the Sheriff Mills sent their daughter, Abby, to live with family in LA and she hasn't returned since. After 7 years, Abby is finally returning to the island for her best friend Henry's wedding but now the killing starts again and everyone is a suspect. The guests manage to unlock secrets of the island and of Wakefield as the series progresses.