Humans had known of Kaferian apples as early as 2151, as it was on the cover of a noted interplanetary guidebook. (ENT episode: "Strange New World") When Lieutenant Commander Gary Mitchell became mutated into a superbeing in 2265, he had the ability to create a Kaferian apple tree on Delta Vega. (TOS episode: "Where No Man Has Gone Before") In 2376, Treir served Morn a breakfast plate of Skorrian fritters in a Kaferian apple compote. (DS9 - Mission Gamma novel: Twilight)
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