USS Castine (IX-211) was a ship in the United States Navy. She was originally named PC-452, a submarine chaser. PC-452 was laid down on 14 March 1940 at the DeFoe Boat and Motor Works in Bay City, Michigan, as Hull #167, under the Experimental Small Craft program of 17 May 1938. She was launched on 23 August 1941 and towed to the Philadelphia Navy Yard to be fitted out with boilers; and commissioned as USS PC-452 on 1 May 1944.