Resident Evil Uprising is a direct sequel to the mobile game Resident Evil: Genesis; an alternate take on some of the series' memorable events. Using the same engine as Genesis, the game environment is divided into isometric squares, much like the previous game. The movements and backgrounds are static, and players take control of Claire Redfield and Leon Scott Kennedy in a third person-perspective. The game is a reimagining of the classic Resident Evil 2. But unlike in RE2, the main gameplay feature of Uprising is the partner zapping system, a gameplay element previously used in Resident Evil 0: instead of choosing either one of two characters at the beginning, there are two protagonists to be controlled throughout the entire game. The player may switch between Chris Redfield's sister, Cl