Francesco Piccolomini (12 October 1582, Siena (Italy) -17 June 1651, Rome) was an Italian Jesuit, elected the 8th Superior General of the Society of Jesus. After Vincenzo Caraffa, the 7th Superior General of the Order, died on 8 February 1649, a General Congregation made of representatives of the various Jesuit provinces, met on 21 December of the same year and chose Piccolomini as his successor. He died after eighteen months in office.