She made her debut in the first game where she is at first an enemy of Frank West, but turns face when her brother leaves her for dead. In the game's "true ending," she helps temporarily subdue Frank's infection, and escapes with him out of Willamette. Her legacy is the drug Zombrex, which is a main plot device in Dead Rising 2 (in which she is mentioned by name but does not appear in, she does however make an appearance in Dead Rising 2: Case West). Isabela also makes an appearance in Dead Rising 3.