Lepine played in the National Hockey League from 1925 to 1939, spending his entire career with the Montreal Canadiens, winning two Stanley Cups, in 1930 and 1931. Lepine, a center, played over 500 games with Montreal and was an excellent goal scorer who could also check and battle for the puck in the corners. In his rookie NHL season (1925–26), he scored nine goals and played on the same line as a his older brother, Hec. He had played senior hockey in Montreal with the Montreal Royals, Hochelaga and Montreal Nationale squads.