The Angel island mouse or La guarda deermouse (Peromyscus guardia) is a species of rodent in the family Cricetidae. It is endemic to Mexico, where it is historically known only from the island of Ángel de la Guarda, and nearby islets. The species is believed to be extirpated from the three smaller islands, and may be extinct on Ángel de la Guarda as well. The species is threatened by predation by feral cats, and by competition from introduced rodents.