The game begins with Inky and Clyde giving the main villain, Mollusc, a golden Power Pellet known as the Artifact. Mollusc destroys the Artifact, scattering its pieces into 5 key periods of time itself. To prevent the Artifact from ever being destroyed, Pac-Man journeys via time machine, through the Prehistoric Era, Egyptian Times, Medieval Times, the Wild West, and the future while evading the Ghosts in different appearances.