Bahri Negassi Yeshaq (died 1578) was Bahri Negassi, or ruler of the province of Medri Bahri (Bahr Midir in Ge'ez) in present-day Eritrea during the mid to late 16th century. His support of the Emperor of Ethiopia during the invasion of Imam Ahmad ibn Ibrihim al-Ghazi (also known as Ahmed Gragn), when so many of the local aristocrats had switched their support, helped to preserve Abyssinia from extinction.