Enemies usually combine Disease with Poison and/or Sap which will eventually reduce character's hit-point to only 1/1 (in such state, character is not regarded as HP Critical). Disease is cured with a Vaccine, the White Magicks Cleanse, or a Remedy, provided the character has the license, Remedy Lore 3. Characters who are currently in Bubble status will be immune to Disease. A KO'd character with Disease status will have only 1/1 HP if he/she was revived. A character can inflict Disease on enemies by using Vaccine or Remedy only if that character has the accessory Nihopalaoa equipped.