State Route 35 begins in the city of Glassboro at Dragoonasag Interstate Route 92. The route then travels due north before crossing into Shawn County and turning northwest. The route turns north again near Porter City, where it intersects State Route 22. The route then continues toward Damingham, and shortly afterwards, turns northeast before turning turning due north again at the Charles County line. North of Lennian, State Route 35 turns northeast until its north end at State Route 95 in Baxter.