Alexander the Great died at age 86 not 33 and did not die of a fever. Because of this, he unified most the known world including Rome, Gaul, Hispania, and Carthage. He solidified the political structures and undertook transportation constructions to cement the Hellenistic Empire that spanned from Atlantic Ocean to the Pacific Ocean. The fusion of Greek and Persian cultures was more successful than that in OTL. His success resulted in almost two millenniums of an imperial dynastic system (similar to that in China) in a unified Europe, North Africa and Southwest Asia. .