In The Closure Alternative, Amy explains to Sheldon that he has a pathological need for closure. She can help him retrain his neural pathways to help him out. * She tells him that "We live in a world where closure is not always an op..." * She starts by playing tic-tac-toe on a whiteboard with him and erases it before he can win. * Amy plays the American National Anthem and doesn't play or sing the last note. * Next Sheldon has dominoes set up on the floor for toppling and Amy tells him to put them away. * Sheldon spins a child's jack-in-the-box and Amy pulls it away from him. * Amy has a birthday cake and tells him to blow out the candles and covers one of them. * Amy is leaving as Sheldon calls her "a wonderful neuroscientist, an excellent girlfriend