Five years after the events of the original film, The Toxic Avenger (Ron Fazio) is lured to Tokyo, Japan by the evil corporation Apocalypse Inc. So while the Toxic Avenger is fighting crime in Tokyo, Apocalypse Inc. spreads evil in Tromaville and it is up to the famous hideously deformed superhero of superhuman size and strength to stop the abominable Apocalypse Inc. from attacking both Tokyo and Tromaville.