Dracula has obtained both halves of Tekamentep's Ankh and has most of Spider-Man's team under mind control. In order to stop him activating the Ankh before sunrise, Spider-Man and Blade join forces with Nick Fury's Howling Commandos (a S.H.I.E.L.D. task force consisting of various heroic monsters) and travel to Dracula's castle in Transylvania to retrieve the Ankh.