German submarine U-353 was a Type VIIC U-boat of the Nazi German Kriegsmarine during World War II. The submarine was laid down on 30 March 1940 at the Flensburger Schiffbau-Gesellschaft yard at Flensburg, launched on 11 November 1941, and commissioned on 31 March 1942 under the command of Oberleutnant zur See Wolfgang Römer. After training with the 5th U-boat Flotilla based at Kiel, U-353 was transferred to the 1st U-boat Flotilla at Brest in France for front-line service from 1 October 1942.