She became interested in Issei in Volume 11 because of the changes that have taken place for Ddraig, and asked the latter whether he wants to be a Heavenly Dragon or an Oppai Dragon, and talks about the changes in Ddraig's powers and unusual powerups of his host because his color of armour has changed to crimson instead of his normal red in Cardinal Crimson Promotion state. Ophis plays a big part in Issei's revival in Volume 12 along with the Great Red, who gave Issei part of his flesh, by giving him a portion of her powers. Ophis described Issei as a lecherous faced father.