Presley performs the song as part of a medley with "Get Back" in the 1970 rockumentary film Elvis: That's the Way It Is. The song would later be covered by such artists as Dwight Yoakam, Robert Plant, The Nighthawks, The Staggers, Pearl Jam, Ry Cooder and Jesse and the Rippers. The song lyric makes mention of "Jim Dandy" which was the title of a 1956 song "Jim Dandy" by LaVern Baker. An answer song to "Little Sister", with the same melody but different lyrics, was recorded and released under the title "Hey, Memphis" by Baker on Atlantic Records (Atlantic 2119-A) in September 1961.