USS SC-255, sometimes styled as either Submarine Chaser No. 255 or S.C.-255, was an SC-1-class submarine chaser built for the United States Navy during World War I. Like most members of her class, she was not named and known only by her designation. SC-255 was built at George Lawley & Sons in Neponset, Massachusetts in 1917. She was commissioned 19 November 1917. At some point in her career, SC-255 entered dry dock in Malta. SC-255 was sold on 24 June 1921 to Joseph G. Hitner of Philadelphia. Her ultimate fate is unknown.