Agnese Sanctis is a character from the light novel, manga, and anime series A Certain Magical Index. She's a member of the Roman Orthodox Church and is the leader of her own personal forces, the Agnese Forces, and is the former main antagonist of the Orsola Aquinas Rescue Arc where she tries to kidnap Orsola Aquinas on charges of heresy for defecting from the Catholic Church for trying to decode the infamous Book of the Law and was eventually defeated. Eventually, Agnese is saved by both Touma Kamijou and Orsola and eventually redeems herself where she ends up joining Necessarius and acts as the representative of the Catholic faith to England and the English Puritan Church. She is voiced by Rie Kugimiya in the Japanese version of the anime and Alex Moore in the English version.