The USS Syracuse (NCC-60503) was a Nebula-class starship in service with Starfleet in the late 24th century. As of 2376, the Syracuse was under the command of Captain Raymond Alverez. Lieutenant Commander Wesley Crusher served as main science officer aboard the Syracuse. The Syracuse was armed with transphasic torpedoes and quantum phasers, along with a new XJ-255 sensor network. The Syracuse, in 2376, searched for the missing SS Seattle, which had been destroyed by a Tholian warship. A Starfleet tactical wing rendezvoused with the Syracuse and engaged the Tholian ship, destroying it.