Zhian'tek Syndrome is a rare condition in which the synaptic connections between a Trill host and symbiont become disrupted through the transporter process. About one in 10,000 joined Trills suffer from this condition. When a joined host-symbiont pair is put through a transporter beam, the condition causes the isoboramine levels in the host to become abnormally lowered, which causes an involuntary separation between host and symbiont. This result, unless the effect can be reversed, is inevitably fatal for the host and on occasion the symbiont as well. (Starship Independence)