In 1943, she was sent to the Mediterranean, where she performed screening duties for major naval units. HMS Troubridge was one of the units that performed as a screen for HM Cruisers Aurora, Newfoundland, Orion, Penelope and Euryalus, in conjunction with Mediterranean Fleet destroyers and Motor Torpedo Boats for the surrender of Pantellaria on 10 May 1943. She provided support to offensives on Italian warships, provided anti-aircraft support, and was involved in the Allied effort to land in Sicily, Calabria, and Salerno. Other notable events involving HMS Troubridge was the sinking of the German submarine U-407. U-407 was sunk in the Mediterranean south of Milos, in position 36º27'N, 24º33'E, destroyed by depth charges dropped from HMS Troubridge, HMS Terpsichore, and the Polish destroyer