Dr. Diabole was self-billed as “the world’s greatest scientist." However, while searching for radium in the jungles of the Amazon, he contracted a rare flesh eating virus that left his face basically a skull and drove him insane. The doctor enlists John Doyle, also known as the heroic Zebra, to help him. However while investigating some strange mass poisonings, Zebra discovered the culprit was none other than Dr. Diabole.