Dr John Fletcher Little (1843 - 9 August 1914) was a surgeon and local politician active in the Marylebone area. Born in County Tipperary, Ireland, he received his initial medical training in Dublin and practiced medicine in Liverpool and the United States before moving to London. He was awarded a MRCP diploma by the University of London in 1889, and established a practice at 32 Harley Street. Little became a member of the Marylebone Vestry, and was also active in the Liberal Party, standing unsuccessfully as the party's candidate at Oxford at the 1895 general election.