USS S-46 (SS-157) was a third-group (S-42) S-class submarine of the United States Navy. Her keel was laid down on 23 February 1921 by the Bethlehem Shipbuilding Corporation in Quincy, Massachusetts. She was launched on 11 September 1923 sponsored by Miss Grace Roosevelt, and commissioned on 5 June 1925, Lieutenant Commander Hubert V. LaBombard in command.