The .45 Defender is a weapon that appears in Uncharted 2: Among Thieves, Uncharted 3: Drake's Deception and in Uncharted: Golden Abyss. In the second game, it replaces the PM-9mm from Uncharted: Drake's Fortune as the first (chronologically) firearm. Despite power differences between the 9mm and .45 calibers, both weapons are largely the same performance-wise.