The game was co-developed by Capcom and Cavia and produced by Masachika Kawata, who was behind the PS2 port of Resident Evil 4. At E3 2006, Capcom officially announced that development was already underway for an exclusive Resident Evil game for the Wii and mentioned that it would take advantage of the console's unique Wii Remote controller, giving players a new experience in the series' franchise. Members of Capcom's Clover Studios, who created such games as Viewtiful Joe and Ōkami, were called upon to help develop the game.