The film is set in the Midwestern American Raccoon City, whose citizens have been transformed into zombies after becoming infected with the T-virus, a biological weapon secretly developed by the pharmaceutical company Umbrella. A military squad – consisting of leader Claus (Masaki Aizawa) and his men Roger (Hiroto Torihata), Ed (Hideto Ebihara), Robert (Tadasuke Omizu) and Norman (Yoshiyuki Kaneko) – is sent into the city by the company. Members of the Umbrella Biohazard Countermeasure Service, a group specialized in containing biohazard outbreaks caused by Umbrella, their objective is to rescue Dr. Cameron (Yurika Hino), a female scientist researching a new virus.