Ed is first seen jogging with his friend Adam. When he gets home, he asks Elise for something with electrolytes because he doesn't feel well. However, he finds her still in bed and reminds her she hasn't been to work in days. When he tries to rouse her, she snaps at him and they both realize she needs medical attention. Ed becomes increasingly upset as House does no better than the six doctors before him and can't come up with anything that will make his wife feel better. Elise realizes that Ed isn't going to come back.