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The Toxin was a bioweapon manufactured by the Romulan Star Empire in the mid 22nd century. The artificially created disease was a mutagenic virus that was created by the rogue Vulcan scientist T'Uerell who created it using Borg knowledge from the civilizations that the Borg Collective had assimilated. It was the outcome of an alliance made between T'Uerell and the Romulan's; the latter provided her with Protomatter as part of the exchange. The disease was not given a formal name within the game and was referred to as the "Toxin", "Disease" and as a "mutagenic virus".

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