Sepé Tiaraju (unknown–1756) was an indigenous Guarani leader in the Jesuit reduction mission of São Luiz Gonzaga and who died on February 7, 1756, in the municipality of São Gabriel, in the present-day state of Rio Grande do Sul, Brazil. Sepé Tiaraju led the fight against the Portuguese and Spanish colonial powers in the Guerras Guaraníticas (Guarani War) and was killed three days before a massacre that killed around fifteen hundred of his fellow warriors. After 250 years of the date of his death he still remains a very influential figure in the popular imagination, considered a saint by some.