As a young adult, she was friends with Geordi La Forge, who considered her beautiful and full of life. Santorini in turn considered La Forge to be her best friend, and told him so just before she left for Serafin's Planet, a colony for others suffering from the same disease. She was later fatally attacked by her fellow colonists, who feared her relationship with La Forge weakened her resolve and endangered their survival. She told La Forge she would always love him just before dying in sickbay. (TNG comics: "Serafin's Survivors", "Shadows in the Garden")