Legio II Isaura was a pseudocomitatensis Roman legion, levied no later than under Diocletian, and possibly already present under Probus. As their name suggests, II Isaura and its twin legion III Isaura were guarding the Isauria territory at the time of the Notitia Dignitatum, to defend it from the incursions of the mountain peoples. It is possible that in the beginning they were supported by I Isaura Sagittaria.