John Snyder Carlile (December 16, 1817October 24, 1878) was an American merchant, lawyer, and politician, including a United States Senator. A strong supporter of the Union cause during the American Civil War, he represented the loyalist faction of Virginia, which was eventually separated into two distinct states over his protests. Following the war, Carlile retired from politics and returned home to resume his law practice. He died in Clarksburg, West Virginia, and was buried in the Odd Fellows Cemetery.