Secretary of State: Richard Holbrooke Secretary of the Treasury: Mary Ellen Withrow Secretary of Defense: Tony Lake Attorney General: Janet Napolitano. Secretary of the Interior: Tom Udall Secretary of Agriculture: Tom Vilsack Secretary of Commerce:Alexis Herman Secretary of Labor: Benjamin Cayetano Secretary of Health and Human Services:Jeanne Shaheen Secretary of Housing and Urban Development: Thomas Menino Secretary of Transportation:Corrine Brown Secretary of Energy: Jennifer Granholm Secretary of Education: James Baxter Hunt Jr. Secretary of Veterans Affairs: Charlie Gonzalez Secretary of Homeland Security: Susan Collins