USS Champlin (DD-601) was a Benson-class destroyer in the United States Navy during World War II. She was the second ship named for Stephen Champlin. Champlin was launched 25 July 1942 by Bethlehem Steel Company, Fore River Shipyard, Quincy, Massachusetts; sponsored by Mrs. A. C. Brendel; and commissioned 12 September 1942, Lieutenant Commander C. L. Melson in command.