The airfield was operated by No. 54 Operational Base Unit. The first unit to arrive was No. 31 Squadron, equipped with Bristol Beaufighters, in November 1942. No. 1 Photo Reconnaissance Unit (1PRU) arrived at the airfield in 1943 equipped with P-38 Lightnings, de Havilland Mosquitos and CAC Wirraways. 1PRU was re-designated No. 87 Squadron RAAF on 10 September 1944. In November 1944, three Dakotas from No. 34 Squadron were detached to the airfield, prior to staging north of Australia. Part of Leg 9 of The Amazing Race 9 was conducted at Coomalie Creek Airfield.