Nolasco started the 2008 season as a middle reliever, but quickly found his way to the top of the rotation as Florida's top starting pitcher. On August 19, 2008, he pitched a two-hitter against the San Francisco Giants. With one out in the 9th inning, he gave up a double; the only other hit given up by him was a ball deflected off the glove of first baseman Mike Jacobs. Nolasco also had a two-run double in the game. Nolasco won 15 games in 2008, putting him in the top 5 in wins in the National League.